Clinicians may soon have an effective therapeutic weapon against the serious health hazards posed by obesity and the metabolic syndrome.

Ideally, basal insulin therapy should provide adequate and reproducible steady-state plasma insulin levels without causing hypoglycemia. Our expert reviews the current basal insulin options when patients fail oral antidiabetic drugs.

Job strain after first MI linked to future heart problems; Adding single insulin to oral drugs fails most diabetics; Screening not equally useful in all chest-pain patients; HDL predicts risk of major cardiovascular events

CABG or PCI? It's a dead heat; Diabetes regimens: For some, the treatment is worse than the disease; News from the FDA

A 97-year-old woman with mental changes and polyuria

Are women with polycystic ovary syndrome at increased risk of cardiovascular disease and, if so, what preventive measures need to be addressed?

At the ADA: Glitazones on the mat and other concerns

Diabetic foot ulcers

Weight loss and increased physical activity can prevent or delay diabetes by overcoming insulin resistance. Diet and exercise are more effective in preventing diabetes than are glucose-lowering drugs.